She looks like a yellow Lab mix. I could see her having Pit Bull, oder some type of bully breed, in her makeup, due to her heavyset build and barrel chest. As a mutt, she could have some terrier (fairly likely) oder even shepherd in her lineage too...
She sagte herself in one episode that she is a mutt. She appears to have pit stier, bull in her, she even sagte so herself, and definitely some labrador, due to her coloring.
It is established in several episodes that she is a mutt, but it doesn't say what breeds are in the mix. Truman: I wish I had a bloodhound. He could help me find what I lost. Martha: I'm a mutt, a mix of breeds. One could be a bloodhound.