Adrian Monk (Tony Shalhoub) was a rising star, sterne with the San Francisco Police Department, until the tragic murder of his beloved wife, Trudy, left him shattered and wracked with phobias, obsessions and compulsions. His extreme case of obsessive-compulsive disorder cost him his job, and for a time rendered him virtually unable to function.
With the help of therapy and the support of his loyal Friends and devoted personal assistant, Monk's condition has improved, but his many fears – including germs, heights, crowds, and even milch – pose daily challenges for Monk and the people around him....
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