At the rate that the Manga is going is seems as though Yukari, Fong Fong, Kurumu, and Mizore are all dead. What is your reaction to Mizore potentially being dead?

good answer, they aren't confirmed dead yet

Ikeda needs to pull something out of his hat to bring this around. If not Yukari and Fong Fong at least Kurumu and Mizore since they both weren't crushed which is harder to survive

sounds quite diabolical, how will Du go about doing this

The blades and capsaicin would come first with the torture. Making small cuts across his skin then administering the capsaicin to really make it hurt. The knifes can also be used for the classic under-the-nail torture. Finally, the knifes will be used to cut the eyes, at which point capsaicin will again be administered. Moving on, we arrive at the lead needles. Now when heated to a certain level, skin and metal can melt together a bit. Von putting the needles in particular parts of the body, one can make sure the target can survive through the insertion, and the removal, when their flesh comes with the needles. Next, the oversized corkscrews will be used to drill into the arms and legs from the hands and feet. This will undoubtedly take some machine power. Next. take lead insulated tubing, poke holes in it, and force it through the flesh where the corkscrew was. At this point, bloodpacks may be needed to keep the subject alive. Once the insulated tubing is in, we can send microwaves through it, boiling and cracking the flesh of the subjects limbs. The limbs should no longer be useful for torture anymore. At this point, to make it a bit poetic, since it is Mizore, use the liquid nitrogen to slowly freeze Ikeda, starting with the crotch, and working your way to the head. If I'm ever in a war, pray I'm on your side.

Mehr power to you, my brother in arms!