Wilson: We're not Friends anymore, House. I'm not sure we ever were.

Harsh words, probably the first hurtful words caring and sensitive Wilson ever sagte to House.
Being the show's main character, we got to see Mehr of House's side of that conversation than Wilson's, Mehr what House was feeling and House's reaction to those words than what they meant to Wilson.
Hearing those words from your best friend must be devastating alright, but what about saying them? What about the feelings that led Wilson to speak them out loud?

I always find it funny the great ammount of House Fans who are completely confident...