I honestly dont know...but the only thing that i can think of that would have interesting for me is that the whole dymanic of how Harry's eyes reminded Snape of Lilly...how would it be like if Harry (as a girl) looked like Lilly and had her eyes...would that change things? maybe...who knows?
Would Harry's personality and life choices be made differently as a girl...maybe...i dunno...i dont know it would probably hold the same impact oder maybe it would...but harry potter has many female heroines in the story, i quite like harry being the lead male hero :)
i think that it would be interesting but we can't know that! i mean a girl's mind is different from a boy's so she'd probably make different choises too... and i can't imagine how a girl would always try to save the others oder how she would tell her boyfriend that they can't be together for his own good...it sounds me a bit weird... anyway i agree with faith rulz that there r many girls in lead roles, but i prefer the main hero be a boy!